These include ABCB6, which is crucial for heme biosynthesis and regulates catalase to protect cells from reactive oxygen species59; PRDX2, a peroxiredoxin that reduces hydrogen peroxide and alkyl hydroperoxides and has an antioxidant protective role60; and MT1, a metallothionein previously shown to control dysfunctional T cells in anti-tumor responses61,62 (Fig. 7d). This evidence concerns the gene CAT and neoplasm.