Analysis of cancer dependency data using DepMap showed that cancer cells commonly depend on all subunits of the eIF2 complex (EIF2S1-3) as well as eIF2B subunits βγδε (Appendix Fig. S9A) (Behan et al, 2019; McDonald et al, 2017; Tsherniak et al, 2017). This evidence concerns the gene EIF2B5 and cancer.