Interestingly, we and others have described a concomitant increase in phosphorylation of eIF2α at serine 51 (S51), a canonical inhibitor of protein synthesis at the translation initiation stage, in several cancer types (Fabbri et al, 2021; Ghaddar et al, 2021; Schmidt et al, 2020; Schmidt et al, 2019). Here, EIF2A is linked to cancer.