To investigate the role of p-eIF2α more precisely in the context of eIF2Bα depletion in CRC, we made use of two well-established mutants: the phospho-dead eIF2α S51A and the phospho-mimicking eIF2α S51D mutants (Donze et al, 1995; Perkins and Barber, 2004; Scheuner et al, 2006; Scheuner et al, 2001). The gene discussed is EIF2B1; the disease is colorectal carcinoma.