The receptor for advanced glycation end products (RAGE) promotes nucleic acid uptake through the endosomes where TLR9 is located, enhancing TLR9-dependent responses and activating the NF-κB transcription factors crucial for immune modulation in cancer and chronic inflammation (Sirois et al. 2013; El-Zayat et al. 2019; Yan et al. 1994; Chuang and Ulevitch 2000; Karapetyan et al. 2020; Chen et al. 2013). This evidence concerns the gene TLR9 and cancer.