Evaluating the expression of the spliced isoform of XBP1, a marker of endoplasmic reticulum stress, and key enzymes in phospholipid biosynthesis (CCTα, CHPT1, and CEPT1)44 (Fig. 1G), we discovered a notable increase in mRNA expression of CCTα, CHPT1, and CEPT1 in mesothelioma cell lines without a concurrent alteration in sXBP1 expression (Fig. 1H). This evidence concerns the gene XBP1 and mesothelioma.