Remarkably, FABP5 silencing induced a significant increase in apoptosis, as evidenced by Annexin-V assay, in both mesothelioma cell lines IstMes2 and MPP89, while apoptosis levels in normal mesothelial cells remained unaltered (Fig. 4C and Supplementary Fig. 2A, B). The gene discussed is ANXA5; the disease is mesothelioma.