This activation enhances cellular proliferation, survival, migration, and differentiation.5,10,11 Furthermore, the kinesin family member 5B (KIF5B)-RET and coiled-coil domain-containing protein 6 (CCDC6)-RET are the most commonly RET fusions which have been identified in 1% to 2% NSCLC patients.12 Per previous clinical experiences, the most RET-fusion NSCLC patients didn’t smoke and were diagnosed at a late stage. This evidence concerns the gene CCDC6 and non-small cell lung carcinoma.