We selected the human H1299 NSCLC cell line for these studies as literature59, CRISPR DEPMAP public data (https://depmap.org/portal/gene/EIF4E?tab=overview) or in-house shRNA targeting eIF4F components, showed that eIF4A1, eIF4E1 and eIF4G1 were essential for H1299 cell survival (Supplementary Fig. 11). The gene discussed is EIF4E; the disease is non-small cell lung carcinoma.