Similar to the active RIIY peptide, compound 4 also significantly inhibited eIF4G:eIF4E binding between 1 and 10 μM in H1299 Non-small cell lung cancer (NSCLC) cell lysates (EC50 ≈ 1.5 μM; Fig. 4f, g). The gene discussed is EIF4G1; the disease is non-small cell lung carcinoma.