To determine the clinical significance of CARM1 overexpression in HCC patients, a correlation analysis between CARM1 expression and clinicopathological features was performed, and the results showed that CARM1 expression was significantly related to tumor size (P = 0.0443), the level of differentiation (P = 0.0239), and satellite foci (P = 0.0272). Here, CARM1 is linked to hepatocellular carcinoma.