MAPT and early-onset autosomal dominant Alzheimer disease: A number of studies have reported that the level of tau protein phosphorylation is significantly increased in acute and chronic central nervous system diseases, such as brain trauma, stroke, hypoxic ischemic encephalopathy, and Alzheimer's disease, as well as in factors such as sleep deprivation and a high‐salt diet, and is closely related to the cognitive dysfunction caused by these diseases [13, 14, 15].