PRKN and myocardial ischemia: Our previous studies demonstrated that mitophagy mediated by PINK1/Parkin plays an essential role in the fine regulation of mitochondrial function in diseases such as sepsis cardiomyopathy, sepsis lung injury, and myocardial ischemia–reperfusion injury and that H2 plays a protective role in these organ injuries by activating the PINK1/Parkin pathway [41, 42, 43].