METTL16 and cancer: Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase and it plays an important role in the process of cancers by forming m6A marks on S-adenosylmethionine (SAM) synthetase pre-mRNA and U6 small nuclear RNA (U6 snRNA).