MAPT and early-onset autosomal dominant Alzheimer disease: We extended this work by providing an in-depth, single-nucleus resolution characterization of PMI-induced transcriptional changes in the brains of 37-week-old (∼9.25-month-old) wild-type (WT) and tau P301S (PS19) mice, a model of tauopathy commonly used in Alzheimer's disease studies (Yoshiyama et al., 2007; Iba et al., 2013).