From this analysis, we identified two genes, MAT2A and AHCY, that upon genetic knockout were associated with reduced cell growth for diffuse glioma (MAT2A gene effect −1.4, p = 3.4 × 10−13; AHCY gene effect −0.335, p = 3.6 × 10−9) and GBM (MAT2A gene effect −1.38, p = 1.7 × 10−10; AHCY gene effect −0.305, p = 2.7 × 10−8) cell lineages (Fig. 1, D and E). The gene discussed is AHCY; the disease is glioblastoma.