The Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 axis is involved in various liver diseases including nonalcoholic fatty liver disease, alcoholic liver disease, and toxicant-induced liver injury.40, 41, 42, 43 Moreover, numerous studies on APAP-induced hepatotoxicity have implicated the involvement of Nrf2. This evidence concerns the gene NFE2L2 and liver disorder.