The overall result is excessive bile acid production during cholestasis and accumulation of potentially toxic bile acids in hepatocytes.38In this regard, Xiao et al.39recently reported that a serum FGF19 level below <107 pg/mL was a significant predictor of cholestasis and liver stiffness in patients with IF, with an OR of 13.184 (95% CI, 4.661–37.289,p < 0.001). This evidence concerns the gene FGF19 and cholestasis.