HES6 and fatty liver disease: Possibly one of the causes of hepatic steatosis in IFALD relates to the transcription factor HES6, which regulates FA metabolism and oxidation.Hes6expression was significantly decreased in a mouse model of 7 days of TPN compared to control mice.Hes6expression was found to be positively correlated with several taurine-conjugated bile acids but negatively correlated with hepatic triglycerides level (R = −0.68).