CD4 and type 1 diabetes mellitus: Regarding T1D-driven autoimmunity, mDPP-4 expression is highest in activated Th17 and Th1 and to a lesser extent in Th2 CD4+ T-cell subsets, presenting particular targets for pharmaceutical intervention (Willheim et al, 1997; Lun et al, 2007; Bengsch et al, 2012).