In recent years, the expression of PFKFB3 being elevated in cancerous tissues and the role that it plays in the process of carcinogenesis have attracted attention while several studies have confirmed that PFKFB3 is overexpressed in breast cancer, CRC, pancreatic cancer, gastric cancer are overexpressed, leading to tumor cell proliferation, distant metastasis, and reduced patient survival.14 This evidence concerns the gene PFKFB3 and breast cancer.