MKI67 and breast carcinoma: There is similarity to what was demonstrated in breast cancer, where a low Ki67 index in metastasis was associated with longer survival independently of primary tumour proliferation.43 Beside TFI indicating aggressiveness of a disease course, analysis of Ki67 in a metastasis may be beneficial to indicate slowly progressing disease as has already been suggested in breast cancer.43 However, more data are needed to draw any firm conclusions.