CD8A and neoplasm: A recent direct comparison of IRE with cryoablation (CA) and thermal ablation further demonstrated that anti-PD1 synergizes best with IRE, leading to longer tumor-free survival, increased infiltration of CD8+ T-cells, and protection against tumor reintroduction.181 Due to the modulation of the immunosuppressive TME, the efficacy of dendritic cell vaccination is improved after IRE.182