Several of these fat-derived hormones (i.e. leptin) have an association with bone metabolism growth.3 Obesity related chronic inflammation with proinflammatory cytokines such as IL-6, TNF-α etc. could contribute to the formation of calcifications, as discs and ligaments of the spine may have receptors for them. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.