COL1A1 and Cirrhosis: Interestingly, the expression levels of CXCL13, TNFSF8, and TNFRSF8 correlated negatively with the expression of retinol binding protein 4 (RBP4) (Fig 3D), which is decreased in cirrhosis [40], and positively with the expression of COL1A1, which reflects liver fibrosis (Fig 3E).