Our analysis revealed that a total of 7 (AMBRISENTAN, MACITENTAN, SITAXENTAN SODIUM, APROCITENTAN, PACLITAXEL, SITAXENTAN, BOSENTAN ANHYDROUS) drugs interact with EDNRB, and 3 (CANDOXATRIL, RACECADOTRIL, SACUBITRIL) drugs interact with MME of NSCLC, as illustrated in Fig 10. This evidence concerns the gene EDNRB and non-small cell lung carcinoma.