To ascertain the role of FGFR2-fusion ECDs, we developed BaF3 and NIH3T3 fibroblast cell lines expressing FGFR2 fusions: FGFR2-BICC1 (the most common fusion found in ICC), FGFR2-AHCYL1, and FGFR2-PHGDH proteins. The gene discussed is PHGDH; the disease is intrahepatic cholangiocarcinoma.