PKA activation results in phosphorylation of microtubule‐associated protein 1A/1B‐light chain 3 (LC3) at the serine 12 residue, leading to inhibition of autophagy, which has a substantial impact on cell death induced by β‐Lap in breast and lung cancer cells overexpressing NQO1. This evidence concerns the gene NQO1 and lung carcinoma.