Given that C. sinensis infection can potently alter the intestinal microbiome, we hypothesized that C. sinensis infection may re-balance dysbiosis of the intestinal microbiota in DSS-induced colitis, which may increase SBAs and activate SBAs/TGR5 signaling pathway, thus, modulating inflammatory responses and ameliorating the severity of colitis. The gene discussed is GPBAR1; the disease is colitis.