We also found that the level of Matrix Metalloproteinase 2 (MMP2) in the colon of non-infection mice, an enzyme capable of cleaving extracellular matrix, thus destroying the intestinal barrier was augmented due to DSS administration, compared with the PBS group (Fig. 2c, P < 0.001); however, in the mice with colitis, C. sinensis infection significantly decreased the expression of MMP2 in the colon of mice, compared with non-infected mice (Fig. 2c, P < 0.01). The gene discussed is MMP2; the disease is colitis.