CD44 and autoimmune disease: Among these, the membrane receptor CD44 may regulate the differentiation of CD4+ T cells through NETs,[22] while CXCR4 is an important chemokine receptor on T cells, particularly in the context of autoimmune diseases.[23, 24] IHC scoring validated that CD44 expression is upregulated in the EAU group, and GSK484 can inhibit the overexpression of CD44 in the EAU group (Figure 6B).