Among these, the membrane receptor CD44 may regulate the differentiation of CD4+ T cells through NETs,[22] while CXCR4 is an important chemokine receptor on T cells, particularly in the context of autoimmune diseases.[23, 24] IHC scoring validated that CD44 expression is upregulated in the EAU group, and GSK484 can inhibit the overexpression of CD44 in the EAU group (Figure 6B). Here, CD4 is linked to autoimmune disease.