Chondrocytes exhibit intrinsic mechanosensitivity owing to the various expression of mechanically‐activated (MA) ion channels, such as Piezo1, Piezo2, and TRP family channels.[17, 18, 19, 20, 59] In order to further explore the mechanotransduction between LIPUS and chondrocytes, we obtained the published scRNA‐seq datasets (GSE211584: arthritis specimens from mice subjected to the ACLR model of PTOA)[60, 61] from NCBI Gene Expression Omnibus for integration and subsequent analysis. The gene discussed is PIEZO1; the disease is Arthritis.