Fusobacterium nucleatum commonly inhabits extensively dysplastic colorectal tissues and adenomas, instigating the secretion of pro‐inflammatory substances such as IL‐6, IL‐8, IL‐1β, TGF‐β, and TNF‐α, thereby fostering the progression of CRC.[268] Garrett WS et al.[269] have demonstrated that Fusobacterium nucleatum adheres to calcium‐binding proteins on the surface of CRC cells via adhesin FadA and Fap2. This evidence concerns the gene TNF and colorectal carcinoma.