[110, 111] After FMT, circulating fibroblast growth factor (FGF)‐19 levels increase, consistent with the activation of the FXR‐FGF pathway, which may help alleviate inflammation and enhance intestinal barrier integrity.[112] FXR activation may promote the recovery from colitis, reduce colonic inflammation, and improve intestinal barrier function.[110] In conclusion, FMT restores bile acid metabolism, particularly BSH function, and activates the FXR‐FGF signaling pathway, providing therapeutic effects against rCDI. The gene discussed is NR1H4; the disease is colitis.