ETBF also inhibits the packaging of miR‐149‐3p in exosomes, thereby promoting selective RNA splicing of KAT2A mediated by PHF5A in CRC cells, ultimately promoting CRC cell proliferation.[146] Additionally, studies have found a downregulation of the farnesoid X receptor (FXR) in CRC patients, resulting in dysregulated bile acid metabolism and further promoting the colonization of ETBF, thereby promoting the occurrence of colorectal tumors.[266] It is known that the subspecies gallolyticus of Streptococcus gallolyticus (Sgg) is closely associated with colorectal cancer. This evidence concerns the gene NR1H4 and colorectal neoplasm.