The goal of this study was to elucidate the role of Nrf2 in a short-term PM<sub>2.5</sub>-induced murine model of CRS.<h4>Methods</h4>C57BL/6 wild-type (n = 12) and Nrf2-deficient (n = 12) mice were intranasally challenged with 400 μg of PM<sub>2.5</sub> or saline alone for 2 weeks. This evidence concerns the gene NFE2L2 and congenital rubella syndrome.