An increase in kynurenate and polyamines (e.g., SPR and SPD) might exert an immunoregulatory effect on the monocyte functions as SPD has been shown to modulate indoleamine 2,3‐dioxygenase 1 (IDO1) enzyme converts tryptophan to kynurenine pathway metabolites.[21] Importantly, the tryptophan metabolism through the kynurenine pathway in the liver can affect liver health, as kynurenine and its downstream metabolites can affect immune function and inflammation, which are involved in liver disease through the gut‐liver axis. The gene discussed is IDO1; the disease is liver disorder.