Survival-associated tumor microbiota may influence the PDAC immune landscape through key signaling molecules such as SYK (45) in the BCR and TCR signaling pathway, relating potentially to a role of tumor microbiome-linked immunity by TCR-mediated CD4+ T-cell activation (46) and BCR-regulated immune response (47) in the pathogenesis of PDAC (12). Here, CD4 is linked to neoplasm.