In summary, through in vitro and in vivo experiments, we have elucidated the interaction between circFOXK2 and PABPC1, and how the circFOXK2/PABPC1 complex maintains the stability of STMN1 mRNA, thereby promoting the occurrence and development of NSCLC. This evidence concerns the gene STMN1 and non-small cell lung carcinoma.