Previous studies have indicated that in esophageal squamous cell carcinoma, PABPC1 fosters both angiogenesis and malignant progression by inducing IFI27 mRNA stability [48], and PABPC1 de‐ubiquitinated by USP10 promotes the stability of CLK2 mRNA to facilitate the development of pancreatic cancer [49]. Here, CLK2 is linked to familial pancreatic carcinoma.