CASP3 and colorectal carcinoma: The underlying mechanism that ISL induces apoptosis in CRC cellsvia activating Caspase 3 and Caspase 9 [31] or through upregulating anti‐apoptotic regulator Bax and downregulating pro‐apoptotic regulator Bcl‐2 [38] have also been verified and our finding firstly demonstrated that ISL downregulates Bcl‐2 as well as upregulates Bax, Caspase 3 and Caspase 9 through TRPV1.