Previous studies comparing mRNA expression levels in human CRC tissues versus normal colon mucosa revealed elevated expression of TRPM8, and TRPV6, while the expression of TRPV1, TRPV4, TRPM4, TRPV3, TRPC6, and TRPV5 was lower in CRC tumor tissues compared to normal tissues [12, 13]. This evidence concerns the gene TRPM8 and colorectal carcinoma.