PLOD1 and polycystic ovary syndrome: For instance, an acute, supraphysiological infusion of insulin under a hyperinsulinemic-euglycemic clamp does not appear to elevate LH in obese PCOS patients or non-PCOS controls; instead, it sometimes has a suppressive effect (Dunaif & Graf 1989, Patel et al. 2003, Lawson et al. 2008).