Holte et al. (1994) also observed PCOS patients with glucose-induced insulin hypersecretion but no insulin resistance, which was more pronounced with increasing adiposity. Misra et al. (2024) observed significantly increased glucose-stimulated insulin secretion in lean PCOS women compared to BMI-matched controls, despite comparable insulin sensitivity in HOMA-IR and QUICKI indices. Here, INS is linked to polycystic ovary syndrome.