INS and polycystic ovary syndrome: It can also act directly on the anterior pituitary to increase LH secretion in rodents (Adashi et al. 1981, Xia et al. 2001), although acutely infusing high insulin does not appear to further elevate LH in obese women with PCOS (Dunaif & Graf 1989, Patel et al. 2003, Lawson et al. 2008).