However, low-dose DHT exposure causes an increase in hypothalamic AKT phosphorylation despite raising peripheral glucose levels (Ubba et al. 2023), and preservation of AKT phosphorylation levels in pituitary tissue similarly contrasts with the hepatic and adipose tissue insulin resistance of low-dose DHT-treated mice (Andrisse et al. 2018). This evidence concerns the gene AKT1 and Insulin resistance.