Constitutive ablation of the anti-apoptotic gene Mcl1 in the intestinal tract of Vil1Cre/Mcl1fl/fl mice has been shown to cause chronic apoptosis and inflammation in crypts, with associated hyperproliferation and dedifferentiation leading to the development of malignant tumours (Healy et al., 2020). This evidence concerns the gene MCL1 and neoplasm.