In concert with our assumption, PARL overexpression markedly ameliorated neuronal loss, mitochondrial injury, and cognitive impairments after Meth exposure; Besides, the Meth‐induced upregulation of PINK1, PGAM5, Parkin, MLKL, RIP1, and RIP3 expression at gene and protein levels was substantially ameliorated, strongly confirming the salutary effects of PARL on Meth‐induced neurotoxicity. The gene discussed is MLKL; the disease is Cognitive impairment.