MAPT and early-onset autosomal dominant Alzheimer disease: Our previous study found that Meth exposure stimulated the expression of Alzheimer's disease (AD) like pathological proteins, including amyloid‐β42 (Aβ42) and phosphorylated tau (p‐tau) [4, 5], which are commonly expressed in the hippocampus, thereby aggravating neuronal damage and underscoring the importance of selecting hippocampal neurons for this study.