Pathologically, the neuronal cells were loosely arranged and decreased, and Nissl bodies were lightly stained or even dissolved compared with PARL overexpression and PGAM5 knockdown cells (Figures 10A and 11A; Figure S3I,J), suggesting that PARL overexpression or PGAM5 knockdown exerts a salutary effect on cognitive and spatial learning against Meth‐induced memory impairments. This evidence concerns the gene PARL and memory impairment.