Consistent with these experiments on cultured endothelium, accumulation of labeled LDL in the mouse aortic arch was reduced 50% by an endothelial cell–specific knockout of Hmgb1, whether on a wild-type or Ldlr−/− background, and atherosclerosis was reduced in the latter compared with the Ldlr−/− single knockout. Here, LDLR is linked to atherosclerosis.