HMGB1 and type 2 diabetes mellitus: The role of DOCK4 in SR-B1–mediated transport of HDL is currently a matter of debate.15,28 HMGB1 has been inhibited in vivo with glycyrrhizic acid, which thereby reduced asthma induced by toluene diisocyanate in mice.29 Investigations of the effect of glycyrrhizic acid and of metformin, another HMGB1 inhibitor, on LDL transcytosis and disease appear warranted because the latter is beneficial overall in type 2 diabetes.