Caveolin-1 (and cavin) is also reduced by MYDGF (myeloid-derived growth factor): Ldlr−/− mice with an additional monocyte/macrophage-specific Mydgf knockout had more LDL transcytosis, arterial LDL uptake, and atherosclerosis than control Ldlr−/− mice, and the effects could be reversed by bone marrow transplantation or MYDFG overexpression.65 Here, LDLR is linked to atherosclerosis.