SCARB1 and coronary artery disorder: (The effect on coronary disease of rare mutations in the SCARB1 gene is under debate.23,24) Estrogen is already known to be atheroprotective, but effects on SR-B1–mediated transcytosis add a new mechanism; G-1 is a specific agonist for GPER,25 through which estrogen affects SR-B1, and that might confer an advantageous, greater effect in arterial endothelial cells than in hepatic cells.