Despite the results of Jang et al,16 inhibition of the LDLR seems an improbable method for reducing atherosclerosis, even in situations where IL-1β is elevated, because the LDLR is strongly antiatherogenic: its absence in familial hypercholesterolemic patients, Watanabe heritable hyperlipidemic rabbits, and Ldlr−/− mice leads to dramatically accelerated disease. This evidence concerns the gene LDLR and atherosclerosis.