In this study, we examined parameters such as CPD, malondialdehyde (MDA), NFkB, and inflammatory cytokines (TNF-α, IL-6, IL-11, IL-10, and IL-12) to understand the molecular and histological changes induced by these exposures, making it a practical and relevant choice for skin cancer research in Indonesia. The gene discussed is NFKB1; the disease is skin neoplasm.