Komara et al. (2016) reported two siblings in a consanguineous Yemeni family with global developmental delay, limited speech, cerebellar hypoplasia, and bipedal ataxic gait [11]. The siblings were found to have a homozygous truncating mutation in the WDR81 gene (R1333X) by whole-exome sequencing, which was confirmed by Sanger sequencing and segregated with the phenotype in affected individuals [11]. The gene discussed is WDR81; the disease is Global developmental delay.