SFN reverses carcinoma cell resistance to cisplatin that may be induced by DNA damage. Additionally, it increases the accumulation of intracellular cisplatin. SFN treatment increases miR-30a-3p expression in cisplatin-resistant cells. SFN enhances A2780/CP70 and IGROV1-R10 cells’ sensitivity to cisplatin treatment. SFN is a key regulator for DNA repair and cisplatin transportation during cancer treatment. The gene discussed is SFN; the disease is carcinoma.