Of note, seven cases were also antiphospholipid antibody (APLA) positive, five cases were positive for rheumatoid factor, three cases showed U1-RNP antibody in association with mixed connective tissue disorder, five cases were DCT positive without features of hemolysis, two cases were associated with small vessel vasculitis, seven cases were associated with hypothyroidism, and there was a single case with anti-TPO antibody positivity. The gene discussed is TPO; the disease is hypothyroidism.