ALB is reported to implicate in various conditions, including diabetes (36), sepsis (37), ischemic stroke (38, 39), Alzheimer’s disease (40, 41), etc. In a 2465-person cohort study, low ALB levels and increased nutritional risk is independently associated with the 30-day mortality in patients with acute disease, with the AUC being 0.77 and 0.75, respectively (42). Here, ALB is linked to early-onset autosomal dominant Alzheimer disease.