The phagocytosis rate was significantly reduced in AATD with Pi*ZZ genotype, compared to the control (Figure 9, p-value = 0.0336), when alveolar macrophages were co-incubated with IgG-coated fluorescent beads (AM:beads ratio 1:5, 1h). The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.