In DM, patients with anti-MDA5 antibodies had higher levels of IFN-α than the others patients (6.58 [0.12-47.16] pg/ml vs 0.14 [0.02-0.22] pg/ml p<0.005) (Figure 3 and Supplementary Figure 2A). This evidence concerns the gene IFIH1 and dermatomyositis.