Taken together, these data support that CuET stimulates i) NKG2D receptor expression on NK and T cells and ii) NKG2D ligand expression, such as MICA/B and ULBP1/2, on tumor cells, thereby facilitating immune recognition and more effective elimination of tumor cells by cytotoxic effector cells (Figure 5E). The gene discussed is MICA; the disease is neoplasm.