Flow cytometry analyses revealed increased NKG2D receptor expression on NK and T lymphocytes treated with 1nM CuET (Figures 4E, F) (Supplementary Figures 6B, C, E, F), as well as a significant increase in NKG2DLs MICA, ULBP1, and ULBP2 on human CRC cell lines HCT116 parental and HT-29, treated with 1nM CuET (Figures 4G, H). This evidence concerns the gene ULBP1 and colorectal carcinoma.