CRC pathogenesis begins through polyp development, progressing to cancer over an estimated 10-15 years due to genetic and epigenetic alterations inactivating tumor suppressor genes (TP53, APC, MADR2, MUTYH, STK11, SMAD2/4, etc.)and activating oncogenes (2). The gene discussed is SMAD2; the disease is colorectal carcinoma.