Interestingly, the CD21low B-cell-related CD11chigh B-cell population in SLE (55, 56) exhibits significant transcriptomic similarities in the expression of glycosylation-related genes, with marked upregulation of ST6GALNAC4, ST6GALNAC6, NEU1, NANS, FUT8, FUCA1, FUCA2, and FUOM (57). This evidence concerns the gene NANS and systemic lupus erythematosus.