Given the prominent role of anti-IgM/IFN-γ stimulation in the differentiation of the naïve-like CD21low B-cell phenotype (5), we compared DEGs from anti-IgM/IFN-γ-activated and unstimulated B cells from HD to DEGs of naïve-like CD21low B cells from CVID patients and naïve CD21pos B cells from HD ex vivo. This evidence concerns the gene CD40LG and Huntington disease.