Among the 30 children that presented with hypsarrhythmia at the time of IESS diagnosis, EEG improvement at three months was seen in 14 of 19 (74%) children receiving ACTH, five of six (83%) receiving oral corticosteroids, and one of five (20%) receiving vigabatrin (p = 0.03 comparing ACTH and oral corticosteroids with vigabatrin; Figure 1C; Table 2B). This evidence concerns the gene POMC and Hypsarrhythmia.