Although PIK3CA or AKT mutations are more common in breast intraductal papilloma, AKT1 E17 K mutation was detected in intraductal papilloma of minor salivary glands, and no genetic alterations (BRAF, PI3KCA etc.)were detected in salivary glands intraductal papilloma with previous reports (6, 17, 18). This evidence concerns the gene AKT1 and intraductal papilloma.