MAPT and Atrophy: Similarly, since amyloid-β deposition and tau protein accumulation in the brain are associated with atrophy in the hippocampus, temporal lobe, medial temporal, and entorhinal cortex, we expected that the neuroimaging patterns that align with neurodegenerative biomarkers are characterized by atrophy in these structures (Killiany et al., 2002; MacLin et al., 2019; Balasaheb Chavan et al., 2023; Igarashi, 2023).