Furthermore, it has been shown that the endogenous amyloid precursor protein (APP) is highly expressed in a heterogeneous subset of GABAergic interneurons in the entire hippocampus, and during the early stages of plaque deposition, interneurons contribute to approximately 30% of the total plaque load in the hippocampus, therefore these cells are likely to have a profound contribution to AD plaque pathology (Rice et al., 2020). This evidence concerns the gene APP and Alzheimer disease.