Reduced somatostatin-like immunoreactivity, potentially indicating loss of SST+ neurons, has been reported in several neocortical areas of patients with AD, including the frontal lobe (Davies et al., 1980; Candy et al., 1985; Beal et al., 1986; Mazurek and Beal, 1991). The gene discussed is SST; the disease is Alzheimer disease.