Conversely, conditional knockout of Snai1 inhibiting the EMT process maintains the integrity of renal tubular epithelial cells and reduces immune cell infiltration in renal fibrosis, while restoring proliferation, dedifferentiation-related repair and regeneration of the renal parenchyma and thereby reducing interstitial fibrosis (Lovisa et al., 2015; Qi et al., 2021) (Figure 1). Here, SNAI1 is linked to renal fibrosis.