WNT1 and chronic kidney disease: WNT1 ligand serves as a key activator of the canonical WNT signaling pathway (Clevers and Nusse, 2012).Overexpression of WNT1 activates β-catenin signaling by binding to Frizzled receptors on the surface of fibroblasts, inducing activation of renal mesangial fibroblasts, promoting the expression of fibronectin, and accelerating the transition from AKI to CKD.