CD4 and infection: Additional studies have shown that naive CD127lowGzmB−CCR7+CD45RA+CD27+CD8+ T-cells, naive CD127lowTIM-3−CCR7+CD45 RA+CD27+CD4+ T-cells, and naive CD127lowTIM-3−CD38lowCD27−IgD+ B cells are absent eight months post-infection in patients with PASC, suggesting ongoing activation of normally naïve T-cell and B-cell subsets (301).