PDCD1 and infection: Following infection with SARS-CoV-2, an upregulation in proinflammatory genes such as HSPA1A in podocytes and JUN1 in mesenchymal clusters (19) can accompany selective immune suppression of lymphocytes mediated through T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) and Programmed cell death protein 1 (PD-1) (20).