Highly reactive, polyclonal CD8+ T-cells have been detected in the serum of patients with a history of mild COVID-19 up to one year after infection (165), with recent studies supporting at least this duration for SARS-CoV-2-specific CD8+ T-cells expressing CD45RA, IL-7R-α, T cell factor 1, and low CCR7 (166). This evidence concerns the gene CD8A and COVID-19.